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. 2018 Feb 16;8:3167. doi: 10.1038/s41598-018-21548-x

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Actuarial analysis of complications after experimental constriction of the mid aortic arch with the RT and DLC techniques. (a) Comparison of mortality estimates shows a significant difference favouring the double loop technique and a concentration of early deaths in the Rockman group and relatively constant attrition rate in the DLC cohort. (b) Comparison of the probabilities of a low transcoarctational gradient not attributable to LV systolic dysfunction (gradient <30 mm Hg with LVEF>50%). (c) Estimates of percent probability of freedom from the combined end-point (death or low gradient) reflect a significant superiority of the double loop technique. (d) Actuarial survival, using the DLC technique, for animals operated of TAC and, TAC+de-TAC. Numbers over the X axis represent the animals at risk for each cohort at the corresponding time point. All comparisons with Gehan-Breslow-Wilcoxon test. TAC: Transverse aortic constriction; de-TAC: Release of TAC.