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. 2018 Feb 16;8:3212. doi: 10.1038/s41598-018-20811-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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In a 21-day therapeutic model AD-114-PA600-6H protected mice from the development of pulmonary fibrosis, reduced hydroxyproline (collagen) content, reduced weight loss associated with bleomycin injury and decreased expression of col1a1 and col3a1 genes. Mice were intratracheally instilled with bleomycin then injected daily with vehicle, or from t = 8–21 days with AD-114-PA600-6H or AMD3100 at 10 mg/kg. Depicted are (A) degree of fibrosis according to the Ashcroft scale³⁷, (B) lung hydroxyproline content, (C) body weights and expression of (D) Col1a1 and (E) Col3a1 genes. N = 5 mice per group, error bars show S.E. In C, statistical significance is shown as **p = < 0.01 as determined following testing of the Vehicle (21 days) against AD-114-PA600-6H using a Two-way ANOVA multicomparison test, Tukey’s posthoc test. In D and E, statistical significance if any is shown as *p = < 0.05, **p = < 0.01 as determined following testing of the Vehicle (8 days) mean against treatment means using a One-way ANOVA, Dunnett’s posthoc test.