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. Author manuscript; available in PMC: 2018 Oct 1.
Published in final edited form as: J Bone Miner Res. 2017 Aug 25;32(10):2062–2073. doi: 10.1002/jbmr.3197

Figure 3. Murine FGF23 c-tail Fc modulates phosphate levels in Hyp mice via regulation of NaPi2A expression.

Figure 3

(A) Serum phosphate values are the averages of 10 mice/grp 24hrs post final dose on D52 and (B) FEPHOSH (ratio of: serum creatinine/serum phosphorus / urine creatinine/urine phosphate) values are the average of serumserum chemistry parameters from10 mice/grp 24hrs post final dose on D52; urine data represents 2 grps of pooled urine from 5 animals/group with collection occurring 12–24hrs post final dosing in non-fasted animals. The necessity to pool urine samples resulted in 2 data points/10 animals and thus prohibited statistical analysis of FEPHOSH. (C) NaPi2A expression relative to B2 microglobulin was assessed from total kidney RNA 24hrs post the final dose on D52 via QPCR. Data represents the average of 10 mice/group. * Significantly different from Hyp control p<0.05; ** Significantly different from Hyp control p<0.01