Figure 4. Normal serum levels of 1,25D and calcium are found following treatment with the murine FGF23 c-tail Fc.
(A) Serum 1,25D values are the averages of 10 mice/grp 24hrs post final dose on D52 and (B) serum calcium values are the average of 10 mice/grp 24hrs post final dose on D52. (C) FECA values (ratio of: serum creatinine/serum calcium over urine creatinine/urine calcium) are the average of serum chemistry parameters from 10 mice/grp 24hrs post final dose on D52; urine data represents 2 grps of pooled urine from 5 animals/group with collection occurring 12–24hrs post final dosing in non-fasted animals. The necessity to pool urine samples prohibited statistical analysis of FECA.
