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Effects of vemurafenib and compound 2d on downstream signaling of BRAFV600E in A375 cells. Vemurafenib (VEM) potently blocked phosphorylation of MEK while 2d had little effects at up to 100 μM. A375 cells were treated with vemurafenib or compound 2d at various concentrations before the cells were lysed, resolved by SDS-PAGE, transferred to PVDF membrane, and probed with antibodies for MEK and phospho-MEK (pMEK).
