Table 3.

Variables Associated with Distant Recurrence (N=893)

Variable	Univariable		Multivariable
	HR (95% CI)	p-value	HR (95% CI)	p-value
Age	1.01 (0.99–1.03)	0.234	1.01 (0.98–1.03)	0.611
Tumor SUV	1.10 (1.06–1.14)	<0.001	1.04 (0.99–1.08)	0.118
FEV1	1.00 (0.99–1.01)	0.454	-	-
DLCO	0.99 (0.98–1.00)	0.246	-	-
Time of Surgery (Tertile)
2000–2006	1.00	-	1.00	-
2007–2013	0.64 (0.41–0.99)	0.045	0.67 (0.41–1.10)	0.113
2014–2016	0.45 (0.23–0.90)	0.023	0.43 (0.20–0.91)	0.028
Tumor Size (cm)	1.40 (1.30–1.51)	<0.001	-	-
Gender
Female	1.00	-	-	-
Male	1.37 (0.92–2.03)	0.121	-	-
Pulmonary Comorbidity
No	1.00	-	-	-
Yes	0.87 (0.54–1.39)	0.554	-	-
Cardiac Comorbidity
No	1.00	-	-	-
Yes	1.51 (1.00–2.26)	0.049	-	-
Histologic Subtype
Lepidic	1.00	-	1.00	-
Acinar	2.58 (0.82–8.09)	0.104	1.82 (0.58–5.66)	0.301
Papillary	2.59 (0.63–10.5)	0.185	1.67 (0.45–6.20)	0.444
Micropapillary	6.12 (1.63–23.0)	0.007	3.16 (0.81–12.3)	0.099
Solid	4.92 (1.58–15.3)	0.006	2.10 (0.62–7.09)	0.234
Other	7.40 (1.25–43.7)	0.027	3.74 (0.65–21.4)	0.139
Visceral Pleural Invasion
Absent	1.00	-	-	-
Present	3.03 (1.95–4.69)	<0.001	-	-
Lymphovascular Invasion
Absent	1.00	-	1.00	-
Present	2.11 (1.41–3.15)	<0.001	1.62 (1.00–2.63)	0.050
pT stage
1a	1.00	-	1.00	-
1b	1.86 (0.97–3.55)	0.060	1.72 (0.89–3.34)	0.107
2a	3.71 (2.10–6.54)	<0.001	2.84 (1.56–5.16)	0.001
2b/3	11.0 (5.80–20.8)	<0.001	6.53 (3.17–13.5)	<0.001
EGFR Mutation
No	1.00	-	-	-
Yes	0.61 (0.26–1.44)	0.257	-	-
KRAS Mutation
No	1.00		-	-
Yes	0.94 (0.46–1.91)	0.861	-	-

DLCO, diffusion capacity of the lung for carbon monoxide; FEV₁, forced expiratory volume in 1 second; SUV_max, maximum standardized uptake value.