Appendix Table 2.

Multivariable Complete Case Analysis (N=622)

Variable	Distant Recurrence		Any Recurrence
	HR (95% CI)	p-value	HR (95% CI)	p-value
Age	1.01 (0.99–1.04)	0.326	1.02 (0.99–1.04)	0.215
Tumor SUV	1.04 (0.99–1.10)	0.107	1.04 (0.98–1.09)	0.177
Time of Surgery (Tertile)
2000–2006	1.00	-	1.00	-
2007–2013	0.68 (0.38–1.24)	0.212	0.71 (0.40–1.25)	0.235
2014–2016	0.46 (0.19–1.08)	0.074	0.46 (0.20–1.05)	0.065
Histologic Subtype
Lepidic	1.00	-	1.00	-
Acinar	2.11 (0.63–7.07)	0.228	1.48 (0.53–4.15)	0.453
Papillary	1.95 (0.53–7.25)	0.317	1.76 (0.58–5.31)	0.317
Micropapillary	4.48 (1.06–19.0)	0.042	3.38 (0.97–11.7)	0.056
Solid	3.20 (0.88–11.6)	0.078	2.18 (0.70–6.84)	0.180
Other	4.70 (0.84–26.4)	0.079	2.91 (0.57–14.9)	0.201
Lymphovascular Invasion
Absent	1.00	-	1.00	-
Present	1.26 (0.71–2.27)	0.432	1.49 (0.86–2.58)	0.154
pT stage
1a	1.00	-	1.00	-
1b	2.07 (0.91–4.72)	0.084	2.13 (0.98–4.61)	0.055
2a	3.25 (1.55–6.83)	0.002	3.25 (1.60–6.58)	0.001
2b/3	6.43 (2.40–17.3)	<0.001	7.86 (3.09–20.0)	<0.001