REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
Monoclonal to c-Myc	Santa Cruz	sc-40
Monoclonal to CUGBP1	Santa Cruz	sc-20003
Monoclonal to CUGBP2	Millipore	04-047
Monoclonal to EIF2AK2	Abcam	ab58301
Monoclonal to EIF2S1	Abcam	ab5369
Monoclonal to ELAVL1	Santa Cruz	sc-5261
Polyclonal to ELAVL2	Abcam	ab209680
Monoclonal to Flag	Sigma	F3165
Monoclonal to G3BP1	BD	611126
Monoclonal to HA	Biolegend	901515
Monoclonal to phospho-EIF2AK2 (T446)	Abcam	ab32036
Monoclonal to phospho-EIF2S1 (S51)	Abcam	ab32157
Monoclonal to phospho-Histone H2A.X (S139)	Millipore	05-636
Antisera against H2B Phosphoserine 14	Kind gift from David Allis
Polyclonal to TIA1	Santa Cruz	sc-1751
Monoclonal to TIAL1	BD	610352
Monoclonal to Tubulin	Sigma Aldrich	T6074-200UL
Polyclonal to phospho-Histone H3 (S10)	Abcam	ab5176
Monoclonal to PACT	Abcam	ab75749
Monoclonal to phospho-CHEK2 (Thr68)	Cell Signaling	#2197
Monoclonal to Caspase-3	Cell Signaling	#9665
Monoclonal to cleaved Caspase-3 (Asp175)	Cell Signaling	#9664
Polyclonal to PARP	Cell Signaling	#9542
Monoclonal to cleaved PARP (Asp214)	Cell Signaling	#5625
Monoclonal to Lamin A/C	Santa Cruz	sc-7292
Polyclonal to UFD1L	Abcam	ab96648
Monoclonal to ALDH7A1	Abcam	ab68192
Monoclonal to SRSF3	Thermo Fisher	33-4200
Polyclonal to SRSF6	Thermo Fisher	PA5-41810
Alexa Fluor 647 goat anti—rabbit IgG	Life tech	A-21244
Alexa Fluor 647 Goat Anti-Mouse IgG (H+L)	Life tech	A-21235
Alexa Fluor 488 Goat Anti-Mouse IgG (H+L)	Life tech	A-11001
Alexa Fluor 546 Goat Anti-Mouse IgG (H+L)	Life tech	A-11030
Alexa Fluor 546 Goat Anti-Rabbit IgG (H+L)	Life tech	A-11035
Polyclonal Goat Anti-rabbit Immunoglobulins/HRP	DAKO	P0448
Polyclonal Goat Anti-mouse Immunoglobulins/HRP	DAKO	P0447
Bacterial and Virus Strains
BL21(DE3) Competent E. coli	NEB	C2527l
One Shot™ TOP10 Chemically Competent E. coli	Thermo Fisher	C404006
Chemicals, Peptides, and Recombinant Proteins
Sodium (meta)arsenite	Sigma Aldrich	S7500-100G
Trizol-LS reagent	Thermo Fisher	10296-028
Critical Commercial Assays
Zero Blunt™ TOPO™ PCR Cloning Kit, with One Shot™ TOP10 Chemically Competent E. coli cells	Thermo Fisher	K280020
Lenti-X GoStix Kit	Clontech	#631244
Deposited Data
Raw sequencing data	This study	SAMN07562375
All raw files of immunoblots or cell cycle analyses were submitted to Mendeley data.		http://dx.doi.org/10.17632/r6czfx3j76.1
Experimental Models: Cell Lines
Flp-In T-REx HEK293 cells	Thermo Fisher	R78007
HEK293T	Dharmacon	#HCL4517
Oligonucleotides
Oligodeoxyribonucleotides/primers are listed in Table S7	IDT	N/A
Oligoribonucleotides:
poly(U)18, poly(C)18, poly(A)18	This study	N/A
poly(U)5, poly(U)6, poly(U)8, poly(U)10, poly(U)15, poly(U)20, poly(U)36	This study	N/A
poly(AUU)6, poly(AAU)6	This study	N/A
AAUUUUUUAA	This study	N/A
AAAUUUUUAA	This study	N/A
AAAUUUUAAA	This study	N/A
AAAAUUUAAA	This study	N/A
AAAAUUAAAA	This study	N/A
AAAUAUUUAA	This study	N/A
AAAUUAUUAA	This study	N/A
AAAUUUAUAA	This study	N/A
Recombinant DNA
Plasmid: px458	Addgene	#48138
psPAX2	Addgene	#12260
pMD2.G	Addgene	#12259
pLenti-C-Myc-DDK-IRES-Puro	OriGene	PS100069
pDONR221	Thermo Fisher	12536017
pET-28a-c(+)	Novagen	#69864
For all plasmids generated within this study see Table S7.
Software and Algorithms
Tophat v2.0.13	(Trapnell et al., 2012)	http://ccb.jhu.edu/software/tophat/index.shtml
Cuffdiff v2.1.1	(Trapnell et al., 2012)	http://cole-trapnell-lab.github.io/cufflinks/
rMATS.3.0.9	Xing Laboratory, UCLA(Shen et al., 2012)	http://rnaseq-mats.sourceforge.net
Cutadapt	http://journal.embnet.org/index.php/embnetjournal/article/view/200/458	https://cutadapt.readthedocs.io/en/v1.8.2/installation.html
R Studio Version 0.98.1060	Rstudio	https://www.rstudio.com/
Prism 7 for Mac OS X	Graphpad	https://www.graphpad.com
ImageJ 1.48v		http://imagej.nih.gov/ij
PARalyzer	(Corcoran et al., 2011; Mukherjee et al., 2014)	https://ohlerlab.mdc-berlin.de/software/PARalyzer_85/
PAR-CLIP suite	(Garzia, Meyer, Morozov, Sajek, & Tuschl, 2017)	https://rnaworld.rockefeller.edu/PARCLIP_suite/