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. 2018 Feb 13;9:92. doi: 10.3389/fphar.2018.00092

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Copyright © 2018 Sun, Zhu, Li, Wang, Tang, Su, Li, Zheng and Feng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Scutellarin enhanced the drug susceptibility of cisplatin in A549/DDP cell. (A) A549/DDP cells were treated with different concentrations of scutellarin for 24 or 48 h, the cell viability was determined by the MTT assay. (B) Cells were treated with cisplatin combined with scutellarin (80 or 120 μM), cell viability was measured by the MTT assay. (C) The sensitivity of A549 and A549/DDP to cisplatin was measured by MTT assay, and 120 μM scutellarin reduced IC50 of cisplatin in A549/DDP cells. (D) Drug synergism are expressed as fraction affected (Fa) curves and combination index (CI) plots. CI as a indicator of synergistic effects of cisplatin and scutellarin (additive effect, CI = 0.9–1.1; slight synergism, CI = 0.7–0.9; synergism, CI = 0.3–0.7; strong synergism, CI = 0.1–0.3). ^∗p < 0.05.