Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Feb 13;9:92. doi: 10.3389/fphar.2018.00092

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2018 Sun, Zhu, Li, Wang, Tang, Su, Li, Zheng and Feng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Scutellarin enhanced cisplatin-induced apoptosis through the ERK1/2-mediated p53 signaling pathways. (A) Western blot analysis of p53 protein in A549/DDP cells treated by cisplatin, or scutellarin, or the combination. (B) The effect of p53 inhibitor PFT on p53, caspase-3, cleaved caspase-3 and PARP expression levels was measured by western blot analysis. (C,D) Flow cytometric analysis showing apoptosis in cells treated by cisplatin plus scutellarin, or PFT, or the combination. (E) The expression of p-ERK1/2, ERK1/2 were determined by western blot analysis. (F) The level of p-ERK1/2, ERK1/2, p53 in A549/DDP cells were measured in the presence of ERK1/2 specific inhibitor U0126. Data are representative of three independent experiments (mean ± SEM). ^∗∗p < 0.01.