FIGURE 6.

Scutellarin enhanced antitumor efficacy of cisplatin in vivo. The A549/DDP-Luc cells were subcutaneously implanted BALB/c nude mice, and the mice were treated with cisplatin with or without scutellarin. (A) Tumor growth was monitored by IVIS, representative bioluminescence images of tumor in mice are shown. (B) The tumor dimensions were measured per 3 days using a digital caliper, tumor size in each group is shown. (C) Body weight of each group (n = 8). (D) After treatment for 21 days, mice were humanely euthanized, and the tumor tissues were subsequently harvested. (E) Tumor weight of each group (n = 8). (F) The expression levels of LC3, p62, p53, p-ERK1/2, p-AKT, c-met in mice tumor were detected by western blot analysis. Data are representative of three independent experiments (mean ± SEM). ^∗∗p < 0.01.