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. 2018 Feb 13;9:225. doi: 10.3389/fimmu.2018.00225

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Copyright © 2018 Wagener, Hoving, Ndlovu and Marakalala.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Dectin-1 structure. Dectin-1 consists of an extracellular C-type lectin domain, which is the carbohydrate-recognition domain (CRD) that binds ligands such as β-glucans. The CRD is attached by a stalk to a transmembrane region. Dectin-1 undergoes N-linked glycosylation on the CRD (mice) or stalk region (humans), shown in red and blue, respectively. The intracytoplasmic region comprises an immunoreceptor tyrosine-based activation motif- (ITAM)-like motif, or hemITAM, which initiates intracellular signaling.