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. 2018 Feb 18;12:40. doi: 10.1186/s13256-017-1550-6

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Bone marrow obtained before the initiation of treatment. a Bone marrow smear. Bone marrow is infiltrated by immature myeloma cells showing basophilic cytoplasm and fine nuclear chromatin networks with occasional nucleoli. Binuclear (yellow arrows) and trinuclear (black arrow) myeloma cells, suggesting hyperdiploidies, are seen (under × 40 magnification objective). b Electron micrograph of the bone marrow. Bone marrow is compactly occupied by immature myeloma cells with remarkable nucleoli, fine chromatin networks, and abundant rough endoplasmic reticula