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. 2018 Feb 13;9:207. doi: 10.3389/fmicb.2018.00207

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Copyright © 2018 González-Almela, Williams, Sanz and Carrasco.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Resistance of HCV IRES translation to the eIF2 inhibitor sodium arsenite is independent of eIF2A and eIF2D. HAP1 cell lines WT, HAP1-eIF2A^-, HAP1-eIF2D^-, and HAP1-eIF2A^-/eIF2D^- were transfected with reporter RNAs (HCV-Luc, EMCV-Luc, CrPV-Luc or Cap.βGlobin-Luc) for 1 h and treated with ARS (200 μM) for 2 h. Bars represent the relative luciferase activity with non-treated control (inhibitor concentration = 0) set as 100%. The readings from CHX treatments were subtracted from all as a baseline. Error bars represent the standard error of the mean, n = 3. Statistical significance of the differences between ARS treated samples compared to control was calculated with two-way ANOVA and a Bonferroni post hoc test, and is shown as: ^∗p < 0.05, ^∗∗p < 0.01, ^∗∗∗p < 0.001.