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. 2018 Feb 6;9:61. doi: 10.3389/fphar.2018.00061

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Copyright © 2018 Xiong, Cui, Yu, Wang and Song.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Reduction-responsive disassembly of PEG-CD/AD nanoparticles triggered by DTT. (A) Emission spectra of DOX in PEG-CD/AD solutions containing DTT at different time with an excitation wavelength of 485 nm. [PEG-CD/AD = 40 μg/mL] (B) Hydrodynamic diameter distribution change of PEG-CD/AD nanoparticles treated with 10 mM DTT for 24 h; (C) TEM images of PEG-CD/AD nanoparticles treated without DTT (a) and with 10 mM DTT for 4 h (b) or 24 h (c).