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. Author manuscript; available in PMC: 2019 Mar 1.
Published in final edited form as: Pharmacol Ther. 2017 Oct 31;183:152–159. doi: 10.1016/j.pharmthera.2017.10.014

Figure 1. Nuclear Receptor (NR) Mode of Action and Molecular Topology.

Figure 1

A. The nuclear receptor topology and functional organization consists of distinct N-terminal A/B, a DNA-binding (C, DBD), linker D and C-terminal ligand-binding (EF, LBD) domains. Arrows show locations of the binding sites for ligand, co-activators/co-repressors and the DNA HRE. B. Ligand agonists (green) interact with the receptor (heterodimer of nuclear receptor (NR):retinoid X receptor, (RXR)). Ligand binding is accompanied by the recruitment of co-activators and the basal transcriptional machinery. C. In the absence of agonists or when bound to antagonists (red) the nuclear receptor is maintained in an inactive transcriptional state by co-repressor molecules.