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. Author manuscript; available in PMC: 2019 Mar 1.
Published in final edited form as: Pharmacol Ther. 2017 Oct 31;183:152–159. doi: 10.1016/j.pharmthera.2017.10.014

Figure 3. Ligand-to-DNA Allostery.

Figure 3

Different conformational changes in the ligand-binding pocket induced by distinct ligands (green shapes) can lead to the binding of discrete DNA HRE sequences by the distal DBD through interdomain LBD↔DBD allosteric pathways (blue arrow).