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. Author manuscript; available in PMC: 2019 Apr 1.
Published in final edited form as: Biomaterials. 2018 Jan 19;161:69–80. doi: 10.1016/j.biomaterials.2018.01.027

Figure 7. Improved therapeutic angiogenesis 28 days after HDL-SP administration to a mouse model of diabetic hindlimb ischemia.

Figure 7

(A) H&E and (B) Masson’s trichrome staining 28 days after ischemic injury and injection treatments. Scale bars indicate 100 μm. Immunofluorescent staining of (C) SMA-positive arterioles and (D) CD31-positive capillaries in ischemic muscle 28 days after ischemic injury and injection treatments. Scale bars indicate 100 μm. (E) Fibrotic area in ischemic region quantified from Masson’s trichrome-stained images (n = 15; **p < 0.01 versus HDL-SP group, ++p < 0.01 versus SP group). The density of (F) CD31-positive capillaries and (G) SMA-positive arterioles in ischemic muscle (n = 10~30; **p < 0.01 versus other groups). (H) The average area of SMA-positive arterioles in ischemic region (n = 10~20; **p < 0.01 versus other groups).