Table 1.
Assessment and treatment schedule of study participants.
| Protocol activity | First visit | Wash-out period 1 | Allopurinol (400 mg/day) | Wash-out period 2 | Febuxostat (80 mg/day) |
|---|---|---|---|---|---|
| Day 1 | Days 1-7 | Days 8-21 | Days 22-28 | Days 29-42 | |
| Physical examination | X | ||||
| Serum Cr measurement | X | ||||
| 24-hour urine samples1 | Day 7 | Day 21 | NA | Day 42 | |
| First morning urine sample collected1 | Day 7 | Day 21 | NA | Day 42 | |
| Adverse events | Monitored continuously | ||||
Abbreviations: Cr, serum creatinine. NA, not assessed.
1
2,8-Dihydroxyadenine and creatinine were measured in these urine samples.