Table 5.

Twenty-four hour 2,8-dihydroxyadenine (DHA) excretion and DHA-to-creatinine ratio in first morning void urine samples on allopurinol therapy (400 mg/day) during and following the study.

Patient	Allopurinol1		Allopurinol2
	DHA/24 hr (mg)	DHA/Cr (mg/mmol)	DHA/24 hr (mg)	DHA/Cr (mg/mmol)
2	54	7.0	47	3.5
4	35	2.8	27	3.0
5	90	8.4	88	3.0
6	27	5.6	18*	2.3
7	13*	1.1*	9*	1.0*
8	75	5.1	39*	3.7

¹Allopurinol treatment period;

²during allopurinol treatment following study completion. Abbreviations: Cr, creatinine; ND, not detectable (limit of detection <20 ng/mL).

^*Below limit of quantification (<100 ng/mL).