. Author manuscript; available in PMC: 2019 Feb 15.

Published in final edited form as: Bioorg Med Chem Lett. 2018 Jan 12;28(4):694–699. doi: 10.1016/j.bmcl.2018.01.015

Table 1.

Structural characteristics and inhibitory potency against R132H mutant IDH1 for the synthesized compounds.

Compound	M. Wt.	clogP	Polar Surface Area (PSA)	IC₅₀ vs. IDH1-R132H (μM)
AGI-5198	462.6	4.7	65.0	0.03
1	570.5	5.7	65.0	<0.01
2	492.6	5.8	73.8	1.39
3	535.6	6.4	70. 7	26.31