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. 2018 Feb 14;9:93. doi: 10.3389/fphar.2018.00093

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Copyright © 2018 Laman-Maharg, Williams, Zufelt, Minie, Ramos-Maciel, Hao, Ordoñes Sanchez, Copeland, Silverman, Leigh, Snyder, Carroll, Fennell and Trainor.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of norBNI on immobility in male and female C57Bl/6J mice. (A) Experimental timeline. (B) Average immobility across the four Day 2 trials for male and female C57Bl/6J mice. Immobility scores were analyzed with one-way repeated measures ANOVA testing for drug treatment. ††p < 0.01 compared to vehicle (planned comparison of marginal means). Day 2 immobility for the four trials for male (C) and female (D) mice. For males, n = 5 per group, and for females, n = 6–10 per group. Error bars are SEM.