Table 5.
Hormones, ATP/ADP, ions and nutrients that affect insulin secretion via interaction through GPC.
| Ligand | Receptor | Effect on insulin secretion | Effect on glucagon secretion | G protein | Concentrations (mumol) | ||
|---|---|---|---|---|---|---|---|
| Value | Min | Max | |||||
| ATP/ADP | P2Y | Stimulatory | Not known | Gs | 1 | 0.1 | 1.9 |
| CCK | CCKA | Stimulatory | Stimulatory | Gq | 1 | 0.1 | 1.9 |
| Compound2 | GPR142 | Stimulatory | Not known | Gs | 0.036 | 0.036 | 0.068 |
| Compound21 | GPR142 | Stimulatory | Not known | Gs | 0.036 | 0.036 | 0.068 |
| Glucagon | Gcgr | Stimulatory | Stimulatory | Gs, Gq | 1 | 0.1 | 1.9 |
| GLP-1 | GLP-1R | Stimulatory | Inhibitory | Gs | 1 | 0.1 | 1.9 |
| GIP | GIPR | Stimulatory | Stimulatory | Gs | 1 | 0.1 | 1.9 |
| NPY | Y1 | Inhibitory | Stimulatory | Gi | 1 | 0.1 | 1.9 |
| PACAP | PAC1 | Stimulatory | Stimulatory | Gs | 1 | 0.1 | 1.9 |
| Ach | Ca2+/K+ | Stimulatory | Stimulatory | Gq | 1 | 0.1 | 1.9 |
| AC | cAMP | Stimulatory | No Effect/ Modulating | Gi/o | 1 | 0.1 | 1.9 |
| PLC | IP3/PIP2/DAG | Stimulatory | Inhibitory | Gi | 1 | 0.1 | 1.9 |
| PKA | GPCR | Modulating Secretion | Inhibitory | Gq | 1 | 0.1 | 1.9 |
| cAMP | Epac | Inhibitory | Stimulatory | Gi | 1 | 0.1 | 1.9 |
| DAG analog | PKC | Stimulatory | Inhibitory | Gi | 1 | 0.1 | 1.9 |