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. 2018 Feb 14;11:39. doi: 10.3389/fnmol.2018.00039

Figure 3.

Figure 3

Characterization of DhMLs across standard genomic structures. (A) Modified Manhattan plot of species-specific DhMLs from brain tissue reveals DhMLs to be distributed across the entire human genome. Human-specific and monkey-specific DhMLs are displayed with the –log10 of the raw P-value (y-axis). Significant DhMLs are displayed outside of the dashed lines (genome-wide significance of 0.05 and 0.01), while DhMLs alternate between black and gray to indicate each chromosome. (B) The percent distribution (y-axis) of all CpGs investigated (black), all DhMLs (white), human-specific DhMLs (gray), and monkey-specific DhMLs (red) in each genomic structure are shown. Significant over- and under-representation of DhMLs are indicated (*P < 0.01). (C) The percent distribution (y-axis) of all CpGs investigated (black), all DhMLs (white), human-specific DhMLs (gray), and monkey-specific DhMLs (red) in each island structure are shown. Significant over- and under-representation of DhMLs are indicated (*P < 0.01).