Table 1.
Trypanosoma cruzi ABC proteins.
| Nomenclature | T. cruzi gene ID | NCBI Reference Sequences | Location | Putative protein length | Protein topology in T. cruzi | T. cruzi strain | L. major gene ID | T. brucei gene ID |
|---|---|---|---|---|---|---|---|---|
| ABCA1 | TcCLB.504881.50* | XP_809857 | TcChr27 | 1750 | [TM - NBD]2 | CL Brener Esmeraldo-like | LmjF2.0300 | |
| TcCLB.510045.20* | XP_806887 | TcChr27 | 967 | TM - NBD | CL Brener Non-Esmeraldo-like | |||
| ABCA2 | TcCLB.507099.80 (a) | XP_817325 | TcChr14 | 1836 | [TM - NBD]2 | CL Brener Esmeraldo-like | LmjF11.1220 | - |
| ABCA3 | TcCLB.504149.20* (b) | XP_818098 | TcChr27 | 1750 | [TM - NBD]2 | CL Brener Esmeraldo-like | LmjF11.1240 | Tb927.11.6120 |
| TcCLB.503573.9 * (c) | XP_803907 | TcChr27 | 967 | TM - NBD | CL Brener Non-Esmeraldo-like | |||
| ABCA4 | TcCLB.507099.80 (a) | XP_817325 | TcChr14 | 1836 | [TM - NBD]2 | CL Brener Esmeraldo-like | LmjF11.1250 | - |
| ABCA5 | TcCLB.504149.20* (b) | XP_818098 | TcChr27 | 1750 | [TM - NBD]2 | CL Brener Esmeraldo-like | LmjF11.1270 | - |
| TcCLB.503573.9* (c) | XP_803907 | TcChr27 | 967 | TM - NBD | CL Brener Non-Esmeraldo-like | |||
| ABCA10 | TcCLB.510149.80* | XP_813909 | TcChr36 | 1865 | [TM - NBD]2 | CL Brener Esmeraldo-like | LmjF29.0620 | Tb927.3.3730 |
| TcCLB.506989.30* | XP_818638 | TcChr36 | 1866 | [TM - NBD]2 | CL Brener Non-Esmeraldo-like | |||
| ABCA11 | TcCLB.511725.80 | XP_818719 | TcChr35 | 2260 | [TM - NBD]2 | CL Brener Non-Esmeraldo-like | - | - |
| ABCB1 | TcCLB.507093.260 | XP_820554 | TcChr39 | 661 | TM - NBD | CL Brener Esmeraldo-like | LmjF25.0530 | Tb927.11.540.2 |
| ABCB3 | TcCLB.511537.8* | XP_806158/XP_809384 | TcChr35 | 537 | TM - NBD | CL Brener Esmeraldo-like | LmjF32.3080 | Tb927.11.16930 |
| TcCLB.511021.70* | XP_811319 | TcChr35 | 735 | TM - NBD | CL Brener Non-Esmeraldo-like | |||
| ABCC1 | TcCLB.506417.10 (d) pseudogene | – | ? | 1577 | [TM - NBD]2 | CL Brener | LmjF23.0210 | Tb927.8.2160 |
| ABCC2 | TcCLB.506417.10 (d) pseudogene | – | ? | 1577 | [TM - NBD]2 | CL Brener | LmjF23.0220 | Tb927.8.2160 |
| ABCC6 | TcCLB.509007.99 pseudogene | – | TcChr31 | 1425 | ? | CL Brener Esmeraldo-like | LmjF31.1290 | Tb927.4.4490 |
| TcCLB.507079.30* | XP_805658 | TcChr31 | 388 | NBD | CL Brener Esmeraldo-like | |||
| TcCLB.457101.30* | XP_805394 | ? | 253 | NBD | CL Brener | |||
| TcCLB.508965.14* | XP_815145 | TcChr31 | 765 | TM - NBD | CL Brener Non-Esmeraldo-like | |||
| ABCC9 | TcCLB.510231.29* | XP_805357 | TcChr34 | 854 | TM - NBD | CL Brener Esmeraldo-like | - | Tb927.4.2510 |
| TcCLB.447255.29* | XP_803480 | TcChr34 | 220 | NBD | CL Brener Esmeraldo-like | |||
| TcCLB.506559.100* | XP_821792 | TcChr34 | 1472 | [TM - NBD]2 | CL Brener Non-Esmeraldo-like | |||
| ABCD1 | TcCLB.506925.530 | XP_821597 | TcChr39 | 664 | TM - NBD | CL Brener Esmeraldo-like | LmjF27.0470 | Tb927.11.1070 |
| ABCD2 | TcCLB.508927.20* | XP_804559 | TcChr31 | 674 | TM - NBD | CL Brener Esmeraldo-like | LmjF31.0540 | Tb927.4.4050 |
| TcCLB.509237.30* | XP_814630 | TcChr31 | 674 | TM - NBD | CL Brener Non-Esmeraldo-like | |||
| ABCD3 | TcCLB.510431.150 | XP_819234 | TcChr39 | 635 | TM - NBD | CL Brener Esmeraldo-like | LmjF33.1860 | Tb927.11.3130 |
| ABCE1 | TcCLB.508637.150* | XP_815243 | TcChr10 | 647 | [NBD]2 | CL Brener Non-Esmeraldo-like | LmjF21.0710 | Tb927.10.1630 |
| TcCLB.511913.9 pseudogene | – | TcChr10 | 418 | [NBD]2 | CL Brener Non-Esmeraldo-like | |||
| TcCLB.464879.9* | XP_802148 | TcChr10 | 339 | [NBD]2 | CL Brener Non-Esmeraldo-like | |||
| ABCF1 | TcCLB.504867.20* | XP_812776 | TcChr36 | 723 | [NBD]2 | CL Brener Esmeraldo-like | LmjF3.0160 | Tb927.10.3170 |
| TcCLB.510943.80* | XP_817081 | TcChr36 | 723 | [NBD]2 | CL Brener Non-Esmeraldo-like | |||
| ABCF2 | TcCLB.508897.30 | XP_810886 | TcChr40 | 594 | [NBD]2 | CL Brener Non-Esmeraldo-like | LmjF19.0800 | Tb927.10.15530 |
| ABCF3 | TcCLB.509105.130 | XP_814891 | TcChr37 | 673 | [NBD]2 | CL Brener Non-Esmeraldo-like | LmjF33.0310 | Tb927.10.10880 |
| ABCG1 | TcCLB.506249.70* (e) | XP_806666 | TcChr37 | 665 | NBD - TM | CL Brener Esmeraldo-like | LmjF06.0080 | Tb927.10.7700 |
| TcCLB.508231.190* (f) | XP_818614 | TcChr37 | 665 | NBD - TM | CL Brener Non-Esmeraldo-like | |||
| ABCG2 | TcCLB.506249.70* (e) | XP_806666 | TcChr37 | 665 | NBD - TM | CL Brener Esmeraldo-like | LmjF06.0090 | Tb927.10.7700 |
| TcCLB.508231.190* (f) | XP_818614 | TcChr37 | 665 | NBD - TM | CL Brener Non-Esmeraldo-like | |||
| ABCG3 | TcCLB.506249.70* (e) | XP_806666 | TcChr37 | 665 | NBD - TM | CL Brener Esmeraldo-like | LmjF06.0100 | Tb927.10.7700 |
| TcCLB.508231.190* (f) | XP_818614 | TcChr37 | 665 | NBD - TM | CL Brener Non-Esmeraldo-like | |||
| ABCG4 | TcCLB.506579.10* | XP_811527 | TcChr7 | 700 | NBD - TM | CL Brener Esmeraldo-like | LmjF15.0890 | Tb927.9.6310 |
| TcCLB.507241.39* | XP_806410 | TcChr7 | 290 | NDB | CL Brener Non-Esmeraldo-like | |||
| ABCG5 | TcCLB.504425.70* | XP_813191 | TcChr22 | 1171 | NBD - TM | CL Brener Esmeraldo-like | LmjF23.0380 | Tb927.8.2380 |
| TcCLB.509331.200* | XP_816786 | TcChr22 | 1170 | NBD - TM | CL Brener Non-Esmeraldo-like | |||
| ABCG6 | TcCLB.507681.100 | XP_818599 | TcChr4 | 682 | NBD - TM | CL Brener Non-Esmeraldo-like | LmjF36.2890 | Tb927.10.7360 |
| ABCH1 | TcCLB.510381.20* | XP_807302 | TcChr27 | 303 | NBD | CL Brener Esmeraldo-like | LmjF11.0040 | - |
| TcCLB.506905.40* | XP_806924 | TcChr27 | 303 | NBD | CL Brener Non-Esmeraldo-like | |||
| ABCH2 | TcCLB.509669.30* | XP_816112 | TcChr36 | 318 | NBD | CL Brener Esmeraldo-like | LmjF29.1640 | - |
| TcCLB.509617.80* | XP_809836 | TcChr36 | 318 | NBD | CL Brener Non-Esmeraldo-like | |||
| ABCH3 | TcCLB.511753.100* | XP_812902 | TcChr32 | 496 | [NBD]2 | CL Brener Esmeraldo-like | LmjF30.1330 | Tb927.6.2810 |
| TcCLB.511501.30* | XP_805965 | TcChr32 | 502 | [NBD]2 | CL Brener Non-Esmeraldo-like | |||
| Others | TcCLB.506529.160* | XP_821943 | TcChr6 | 937 | NBD | CL Brener Esmeraldo-like | LmjF12.1190 | Tb927.1.4420 |
| TcCLB.510885.70* | XP_816152 | TcChr6 | 937 | NBD | CL Brener Non-Esmeraldo-like | |||
| Others | TcCLB.508809.30* | XP_809200 | TcChr23 | 1241 | NBD | CL Brener Esmeraldo-like | LmjF33.3040 | Tb927.2.5410 |
| TcCLB.506619.90* | XP_812627 | TcChr23 | 1241 | NBD | CL Brener Non-Esmeraldo-like | |||
| Others | TcCLB.507105.70* | XP_811423 | TcChr35 | 1027 | NBD | CL Brener Esmeraldo-like | LmjF33.3260 | Tb927.2.6130 |
| TcCLB.506817.20* | XP_809803 | TcChr35 | 999 | NBD | CL Brener Non-Esmeraldo-like |
Subfamily names are following to the HUGO nomenclature, according to Leprohon et al. (2006). Gene accession numbers and other informations were retrieved from TriTrypDB (tritrypdb.org) and GeneDB database (http://www.genedb.org/Homepage). Letters after gene accession numbers indicate genes that present more than one nomenclature due to similar phylogeny to different L. major and T. brucei genes. Asterisks represent gene fragments of alleles that represent the same T. cruzi ORF. TM represents transmembrane domain and NBD, nucleotide-binding domain. Protein topology was based in the presence of TMD and NBD in putative protein sequence for each alleles.