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. 2018 Jan 1;8(4):1027–1041. doi: 10.7150/thno.22414

Figure 5.

Figure 5

ALDH2 activation reduces MI/R injury in CCD mice. (A) Representative photographs and quantitative data for infarct size (INF) and area at risk (AAR) (*P < 0.05 vs. CCD vehicle) and (B) casapase-3 activity in hearts from Alda-1-treated or not treated hearts 2 weeks post-CCD followed by in vivo MI/R injury (30 min ischemia/4 h reperfusion); *P < 0.05 vs. no-CCD control; #P < 0.05 vs. CCD alone. (C) Average ejection fraction (EF) and fractional shortening (D) assessed by echocardiography in no pain control or Alda-1-treated or not treated CCD hearts after in vivo MI/R (30 min ischemia/4 weeks reperfusion); *P < 0.05 vs. no-CCD control; #P < 0.05 vs. CCD alone. (E) Survival curves of Alda-1-treated or not treated CCD mice subjected to 30 min cardiac ischemia/8 weeks reperfusion (n=30). *P < 0.05 vs. CCD vehicle. Values are mean ± SEM, n = 6 per group.