Table 2.
Effects of Scutellarin (Scu) on superoxide dismutase (SOD), malondialdehyde (MDA), glutathione (GSH), catalase (CAT), and inducible nitric oxide synthase (iNOS) in rat heart tissue with isoprenaline (ISO)-induced cardiotoxicity (n=6)
| Groups | SOD(U/mgprot)a | MDA(nmol/mgprot)a | GSH (μmol/gprot)a | CAT(U/mgprot)a | iNOS(U/mgprot)a |
|---|---|---|---|---|---|
| G1(saline) | 202.63±26.84c | 1.51±0.35c | 14.082±1.51c | 5.92±0.61c | 0.077±0.043c |
| G2(isoprenaline) | 140.85±16.97b | 4.15±0.65b | 7.53±1.11b | 2.80±1.03b | 0.27±0.048b |
| G3(ISO+10mg/gS.miltiorrhiza) | 224.80±60.25c | 1.74±0.63c | 12.18±3.86 | 5.06±1.22c | 0.12±0.030c |
| G4(ISO+10mg/kgScu) | 221.05±14.06c | 1.845±0.52c | 14.72±2.30c | 3.62±0.53b | 0.14±0.036bc |
| G5(ISO+20mg/kgScu) | 227.38±20.95c | 1.72±0.23c | 17.80±5.41c | 4.67±0.63c | 0.12±0.019c |
| G6(ISO+40mg/kg Scu) | 251.77±21.82c | 1.63±0.40c | 18.41±3.30c | 6.50±1.32c | 0.093±0.038c |
a
Values represent mean±SD of six animals;
b
Significantly different from saline group (G1) P<0.01;
c
Significantly different from ISO group (G2) P<0.01