Table 3. Influence of the potential inhibitors on mevalonate kinase activity.
MVK | DPM | DMAPP | GPP | FPP | Reference | ||||
---|---|---|---|---|---|---|---|---|---|
1 mM | 5 mM | 5 µM | 10 µM | 100 µM | 5 µM | 10 µM | 100 µM | ||
sce | 96 | 8 | nd | nd | 9 | nd | nd | 10 | This work |
mma | 85 | 91 | nd | nd | 96 | nd | nd | 98 | This work |
mcl | 99 | 122 | nd | nd | 104 | nd | nd | 105 | This work |
mpd | 105 | 97 | nd | nd | 101 | nd | nd | 101 | This work |
nmr | 97 | 95 | nd | nd | 100 | nd | nd | 92 | This work |
mja | nd | nd | 58 | 45 | nd | 46 | 35 | nd | [11] |