Table 1.
Clinical, hormonal, and sexual characteristics of the studied sample at baseline and after vitamin D replacement therapy.
| Baseline | Subjects who underwent vitamin D supplementation | P ∗ | |||
|---|---|---|---|---|---|
| Total sample (n = 114) | Before therapy (n = 41) | After therapy (n = 41) | |||
| Clinical indicators | BMI | 29.5 (26.1–31.3) | 28 (25.7–35) | 28.4 (25.4–34.9) | NS |
| Hypogonadism (yes) (%) | 66 (57.8) | 34 (82.9) | NC | ||
| Type 2 diabetes mellitus (yes) (%) | 60 (52.6) | 29 (70.7) | NC | ||
| Dyslipidemia (yes) (%) | 53 (46.4) | 18 (43.9) | NC | ||
| Hypertension (yes) (%) | 51 (44.7) | 16 (39) | NC | ||
| Smoking habit (yes) (%) | 68 (59.6) | 34 (82.9) | NC | ||
|
| |||||
| Biochemical indicators | FSH (IU/L) | 13.6 ± 0.71 | 15.1 (9.3–22.9)a | 15.5 (9.3–20.7) | NS |
| LH (IU/L) | 12.1 (5.7–15.6) | 14.4 (11–16.7) | 10.9 (8.8–16.4) | NS | |
| Total testosterone (ng/mL) | 2.95 (2.77–4.60) | 2.78 (2.27–2.95) | 3.21 (2.64–3.41) | <0.001 | |
| Free testosterone (pg/mL) | 59.4 (54.2–101) | 53.5 (44.3–59.3) | 63.6 (53–71.3) | <0.001 | |
| SHBG (nmol/L) | 31.2 (29.3–32.6) | 32.2 (28.3–34.3) | 29.8 (25.3–35.7)a | NS | |
| Estradiol (pg/mL) | 11.8 (7.8–29.4) | 7.7 (5.5–11.6) | 8.1 (6.4–11.1) | NS | |
| Creatinine (mg/dL) | 0.53 (0.48–0.56) | 0.53 (0.48–0.54) | 0.54 (0.44–0.66)a | NS | |
| 25(OH) vitamin D (ng/mL) | 31 ± 0.59 | 24 ± 0.62 | 38.6 ± 0.89 | <0.001 | |
| PTH (pg/mL) | 55.7 (49.3–60.5) | 62.9 (59.9–75.5) | 39.3 (29.9–49.6)a | <0.001 | |
| Albumin (g/dL) | 4.47 ± 0.019 | 4.44 ± 0.03 | 4.43 ± 0.047 | NS | |
| Calcemia (mg/dL) | 9.33 ± 0.020 | 9.30 ± 0.03 | 9.18 ± 0.069 | NS | |
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| Functional indicators | Erectile function | 18 (11–21) | 10 (8–13) | 11 (9–13.5)a | <0.001 |
| Orgasmic function | 7 (6–8) | 5 (4–6) | 5 (4–6) | NS | |
| Sexual desire | 7 (5–8) | 4 (4–5.5) | 5 (4–6) | NS | |
| Intercourse satisfaction | 8 (7–13) | 6 (6-7) | 6 (6-7) | NS | |
| Overall satisfaction | 4 (3–8) | 3 (3-4) | 3 (3-4) | NS | |
| IIEF total | 44 (32–58) | 29 (25–35.5) | 30 (25.5–36)a | NS | |
Continuous variables are presented as mean and standard error of the mean if normally distributed or as median and interquartile range if not normally distributed. ∗Comparison of the values before and after therapy. aThese data are normally distributed but, in order to present the variable homogeneously, they are expressed as median and interquartile range. BMI: body mass index; FSH: follicle-stimulating hormone; LH: luteinizing hormone; SHBG: sexual hormone-binding globulin; PTH: parathyroid hormone; IIEF: International Index of Erectile Function; NC: noncomputable; NS: not significant.