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. 2018 Jan 23;30(1):e12563. doi: 10.1111/jne.12563

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© 2017 The Authors. Journal of Neuroendocrinology published by John Wiley & Sons Ltd on behalf of British Society for Neuroendocrinology.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Dopamine administration at the peri‐suprachiasmatic nuclei (peri‐SCN) at Zeitgeber time (ZT)13 in high‐fat diet (HFD) fed rats to restore the normal circadian peak of dopamine at this site but not when administered outside this circadian peak window (at ZT19) reduced noradrenergic turnover/activity (3‐methoxy‐4‐hydroxyphenylglycol [MHPG] and MHPG × norepinephrine [NE] product) in both the ventromedial hypothalamus (VMH) and paraventricular nuclei (PVN). (A) PVN MHPG, (B) PVN MHPG × NE, (C) VMH MHPG and (D) VMH MHPG × NE content (pg mg^‐1 tissue) in rats receiving dopamine (2 nmol) or vehicle infusion into the peri‐SCN area at the onset of locomotor activity (ZT13, n = 9 per group) and in rats receiving the same dose of vehicle or dopamine infusion at ZT19 (n = 7 or 5, respectively). Data are expressed as the mean ± SEM. (*P < .05 compared to vehicle treatment, unpaired Student's t test)