| Untreated mock cells versus TBEV-infected cells |
| Canonical pathway |
P-value |
Pathway-associated genes found to be differentially expressed |
| Unfolded protein response |
1,10E-13 |
DDIT3, DNAJB9, DNAJC3, EIF2AK3, ERO1LB, HSP90B1, HSPA1A, PPP1R15A, SEL1L, XBP1 |
| Role of hypercytokinemia/hyperchemokinemia in the pathogenesis of influenza |
5,09E-12 |
CCL3, CCL4, CCL5, CXCL10, IFNL1, IL6, IL15, IL12A, TNF |
| Pathogenesis of multiple sclerosis |
5,93E-10 |
CCL3, CCL4, CCL5, CXCL10, CXCL11 |
| Activation of IRF by cytosolic pattern recognition receptors |
8,51E-10 |
CREBBP, DDX58, DHX58, IFIH1, IFIT2, IL6, ISG15, LTA, PPIB, TNF |
| VDR/RXR activation |
2,39E-09 |
CCL5, CXCL10, EP300, IGFBP5, IGFBP6, IL12A, KLF4, LRP5, MXD1, NCOR2, RXRG |
| Differential regulation of cytokine production in macrophages and T helper cells by IL-17A and IL-17F |
3,15E-09 |
CCL3, CCL4, CCL5, IL6, IL12A, TNF |
| Endoplasmic reticulum stress pathway |
5,06E-09 |
DDIT3, DNAJC3, EIF2AK3, HSP90B1, HSPA5, XPB1 |
| Role of macrophages, fibroblasts and endothelial cells in rheumatoid arthritis |
5,98E-09 |
CCL5, CREBBP, EP300, FGF2, IL6, IL15, IL18RAP, JAK2, LRP5, LTA, MMP13, NFATC1, PLCD4, PLCG2, SFRP2, TCF7L2, TNF, TRAF1, WNT7B, WNT9A |
| Interferon signalling |
7,53E-09 |
IFI6, IFIT1, IFIT3, IRF1, ISG15, JAK2, MX1 |
| Granulocyte adhesion and diapedesis |
9,68E-09 |
CCL3, CCL4, CCL5, CCL3L1, CCL4L2, CLDN1, CXCL2, CXCL10, CXCL11, IL18RAP, MMP13, MMP15, SDC4, TNF |
| Untreated mock cells vs IFN-β-treated cells |
| Canonical pathway |
P-value |
Pathway-associated genes found to be differentially expressed |
| Granulocyte adhesion and diapedesis |
1,43E-07 |
CCL3, CCL4, CCL5, CCL3L1, CCL4L2, CLDN1, CXCL2, CXCL10, CXCL11, IL18RAP, MMP13, MMP15, SDC4, TNF |
| Agranulocyte Adhesion and Diapedesis |
2,00E-07 |
CCL3, CCL20, CLDN1, CLDN14, CXCL1, CXCL2, CXCL3, CXCL5, CXCL8, IL1A, IL1B, IL1RN, IL36RN, MMP1 |
| Differential regulation of cytokine production in macrophages and T helper cells by IL-17A and IL-17F |
4,45E-07 |
CCL3, CCL4, CCL5, IL6, IL12A, TNF |
| Role of cytokines in mediating communication between immune cells |
5,53E-07 |
CSF2, CSF3, CXCL8, IL6, IL1A, IL1B, IL1RN, IL36RN |
| Communication between innate and adaptive immune cells |
6,11E-07 |
CCL3, CSF2, CXCL8, HLA-B, IL6, IL1A, IL1B, IL1RN, IL36RN |
| Differential regulation of cytokine production in intestinal epithelial cells by IL-17A and IL-17F |
1,17E-06 |
CCL3, CSF2, CSF3, CXCL1, IL1A, IL1B |
| Role of hypercytokinemia/hyperchemokinemia in the pathogenesis of influenza |
3,24E-06 |
CCL3, IL8, IL6, IL1A, IL1B, IL1RN, IL36RN |
| Role of IL-17F in allergic inflammatory airway diseases |
4,30E-06 |
CSF2, CXCL1, CXCL5, CXCL8, IL6, IL11, IL1B |
| Role of IL-17A in psoriasis |
7,89E-06 |
CCL20, CXCL1, CXCL3, CXCL5, CXCL8 |
| Hematopoesis from pluripotent stem cells |
2,10E-05 |
CSF2, CSF3, CXCL8, IL6, IL11, IL1A, LIF |
| Untreated mock cells versus IFN-β-treated cells infected with TBEV |
| Canonical pathway |
P-value |
Pathway-associated genes found to be differentially expressed |
| Hepatic fibrosis/hepatic stellate cell activation |
6,85E-11 |
BCL2, COL13A1, COL1A1, COL1A2, COL3A1, COL4A2, COL5A1, COL5A3, COL6A1, CXCL3, CXCL8, ECE1, EGFR, IGF2, IGFBP3, IL6, IL1A, IL1B, MMP1, MMP9, MYH9, MYH14, PDGFA, PDGFRB, SERPINE1, TIMP2 |
| Role of osteoblasts, osteoclasts and chondrocytes in rheumatoid arthritis |
6,79E-08 |
BCL2, BMP5, CBL, COL1A1, FZD7, IL6, IL11, IL1A, IL1B, IL1RN, IL36RN, ITGA5, ITGB3, LRP1, MAP2K3, MMP1, MMP14, NFATC1, PIK3CD, SFRP2, SPP1, TCF7L1, WNT7B, WNT9A |
| Agranulocyte adhesion and diapedesis |
8,17E-08 |
CCL3, CCL20, CLDN1, CLDN14, CXCL1, CXCL2, CXCL3, CXCL5, CXCL8, IL1A, IL1B, IL1RN, IL36RN, MMP1 |
| Granulocyte adhesion and diapedesis |
1,16E-07 |
CCL3, CCL4, CCL5, CCL3L1, CCL4L2, CLDN1, CXCL2, CXCL10, CXCL11, IL18RAP, MMP13, MMP15, SDC4, TNF |
| Atherosclerosis signalling |
2,32E-07 |
APOC1, COL1A1, COL1A2, COL3A1, COL5A3, CXCL8, IL6, IL1A, IL1B, IL1RN, IL36RN, MMP1, MMP9, PDGFA, RARRES3, SELPLG, TNFSF14 |
| Communication between innate and adaptive immune cells |
2,95E-06 |
CCL3, CSF2, CXCL8, HLA-B, IL6, IL1A, IL1B, IL1RN, IL36RN |
| Role of IL-17F in allergic inflammatory airway diseases |
5,92E-06 |
CSF2, CXCL1, CXCL5, CXCL8, IL6, IL11, IL1B |
| Graft versus host disease signalling |
1,26E-05 |
HLA-B, HLA-C, HLA-DRA, HLA-F, IL6, IL1A, IL1B, IL1RN, IL36RN |
| Inhibition of matrix metalloproteases |
1,92E-05 |
HSPG2, LRP1, MMP1, MMP9, MMP14, MMP15, THBS2, TIMP2 |
| Role of IL-17A in psoriasis |
2,74E-05 |
CCL20, CXCL1, CXCL3, CXCL5, CXCL8 |
