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Generation of B- and T-cell responses during immunization. (a) Env-specific IgG-secreting B-cells in PBMC; (b) Env-specific T-cells in PBMC. Both B- and T-cell responses were evaluated by ELISpot assays as described in the Methods section. Data are shown for three macaques, which were vaginally challenged with SIVmac251 on week 83.
