Table 1. Neutralizing antibody response in rabbits immunized with SIVsmE660 gp145 and SIVmac251 gp140 at various weeks after immunization.
Neutralization titres are expressed as the dilution of serum inhibiting infection of TZM-bl cells by 50 % (ID50) compared to the untreated control cells. nd, not determined.
| Animal ID | Bleed week | Neutralization titres ID50 | ||||
|---|---|---|---|---|---|---|
| Tier 1A | Tier 1B | Tier 2 | ||||
| SIVmac251.6 | SIVsmE660-BR/CG7G.IR1 | SIVmac251/M766 | SIVsmE660-BR/CG7V.IR | SIVmac 251.30 | ||
| C2471 | 0 | <20 | 63 | <20 | <20 | <20 |
| 16 | nd | nd | 29 | <20 | <20 | |
| 29 | nd | nd | 35 | <20 | 34 | |
| 35 | 12 882 | 77 916 | 146 | 27 | 57 | |
| C2472 | 0 | <20 | <20 | <20 | <20 | <20 |
| 16 | nd | nd | <20 | <20 | <20 | |
| 29 | nd | nd | 36 | <20 | 35 | |
| 35 | 81 901 | 133 790 | 69 | 26 | 98 | |
| C2473 | 0 | <20 | <20 | <20 | <20 | <20 |
| 16 | nd | nd | 44 | <20 | <20 | |
| 29 | nd | nd | 57 | 26 | 137 | |
| 35 | 31 204 | 94 478 | 133 | 41 | 79 | |
| C2474 | 0 | <20 | <20 | <20 | <20 | <20 |
| 16 | nd | nd | 39 | <20 | <20 | |
| 29 | nd | nd | nd | nd | nd | |
| 35 | 14 859 | 78 935 | 472 | 37 | 98 | |
Data are displayed in a heat map with shades of grey indicating higher nuetralizing antibody titre.
▪40–100, ▪ 100–1000, ▪ >1000.