Table 2. Neutralizing antibody response elicited in Chinese rhesus macaques immunized with SIVsmE660 gp145 and SIVmac251 gp140 at various weeks after immunization.

Neutralization titres are expressed as the dilution of serum inhibiting infection of TZM-bl cells by 50 % (ID50) or 80 % (ID80) compared to the untreated control cells. nd, not determined.

Animal ID	Bleed week	Neutralization titres ID50 (ID80)
		Tier 1A		Tier 1B		Tier 2
		SIVmac251.6	SIVsmE660-BR/CG7G.IR1	SIVmac251/M766	SIVsmE660-BR/CG7V.IR	SIVmac251.30
M907*	0	<20	<20 (<20)	<20 (<20)	<20 (<20)	<20 (<20)
	20	5428 (<20)	29 170 (6735)	<20 (<20)	<20 (<20)	<20 (<20)
	42	9354 (<20)	>43 740 (12 545)	<20 (<20)	2672 (<20)	<20 (<20)
M908	0	<20 (<20)	<20 (<20)	<20 (<20)	<20 (<20)	<20 (<20)
	20	2726 (<20)	>43 740 (26 104)	41 (<20)	7259 (<20)	<20 (<20)
	42	3572 (<20)	>43 740 (12 300)	26 (<20)	5570 (<20)	<20 (<20)
	83 (DOC)	26 129 (49)	>43 740 (26 294)	3664 (24)	5374 (<20)	118 (<20)
	84	15 236 (<20)	>43 740 (24 171)	<20 (<20)	7082 (<20)	<20 (<20)
	85	8794 (<20)	>43 740 (15 850)	<20 (<20)	3862 (<20)	<20 (<20)
M909	0	<20 (<20)	<20 (<20)	<20 (<20)	<20 (<20)	<20 (<20)
	20	2542 (<20)	8125 (1927)	<20 (<20)	<20 (<20)	<20 (<20)
	42	4437 (28)	9189 (2476)	<20 (<20)	<20 (<20)	<20 (<20)
	83 (DOC)	22 974 (122)	>43 740 (12 651)	4672 (23)	1203 (<20)	144 (<20)
	84	16 409 (<20)	29 822 (5179)	<20 (<20)	<20 (<20)	<20 (<20)
M910	0	<20 (<20)	<20 (<20)	<20 (<20)	<20 (<20)	<20 (<20)
	20	5377 (<20)	34 428 (5758)	<20 (<20)	2431 (<20)	<20 (<20)
	42	5626 (<20)	34 792 (5935)	<20 (<20)	<20 (<20)	<20 (<20)
	83 (DOC)	8478 (105)	>43 740 (15 459)	44 (25)	1881 (<20)	56 (<20)
	84	7556 (<20)	>43 740 (18 489)	<20 (<20)	<20 (<20)	<20 (<20)

Data are displayed in a heat map with shades of grey indicating higher nuetralizing antibody titre.

▪ 40–100, ▪ 100–1000, ▪ >1000.

*Animal was euthanized before challenge due to non-vaccine related issues.