Figure 6.

NLRP3 inhibitor MCC950 eliminated the protective effect of H-For on acute colitis in mice. (a) The experimental protocol with For and MCC950 in acute colitis model. (b) Body weights of mice and (c) disease activity index (DAI) during the disease process. (d) Morphological changes in the mice colons, (e) variations of colon length of mice, (f) representative HE staining, and (g) histological scores of colonic tissue. (h) Protein levels of claudin-1, occludin, and ZO-1 and (i) NLRP3, ASC, and IL-1β were analyzed by western blotting. ^∗ p < 0.05, ^∗∗ p < 0.01, and ^∗∗∗ p < 0.001.