Table 2.
Effects of specific activators and blockers on H2O2-induced augmentation of spontaneous contractions in intact bladder strips (Phase 3 values as percentages of Phase 1 values).
| Drugs | n | Basal tension (%) | Amplitude (%) | Frequency (%) |
|---|---|---|---|---|
| Control (vehicle + H2O2) | 13 | 204.6 ± 10.79 | 216.4 ± 22.75 | 100.7 ± 3.00 |
| Nisoldipine + H2O2 | 6 | 195.0 ± 14.81 | 236.9 ± 47.62 | 105.8 ± 5.25 |
| SKF96365 + H2O2 | 6 | 174.2 ± 8.85 | 246.4 ± 56.27 | 101.5 ± 4.95 |
| Ryanodine + H2O2 | 5 | 209.0 ± 20.37 | 253.8 ± 52.82 | 130.4 ± 13.43 |
| Iberiotoxin + H2O2 | 8 | 238.8 ± 13.63 | 339.3 ± 57.82 | 96.6 ± 8.39 |
| NS1619 + H2O2 | 5 | 248.3 ± 16.42 | 318.1 ± 55.97 | 98.8 ± 7.57 |
| Apamin + H2O2 | 9 | 222.5 ± 13.48 | 1025.7 ± 217.71∗ | 84.2 ± 7.39 |
| NS309 + H2O2 | 6 | 208.5 ± 25.43 | 84.49 ± 13.55∗ | 41.2 ± 5.46∗ |
| BIS1 + H2O2 | 7 | 211.0 ± 22.01 | 230.0 ± 31.13 | 104.9 ± 9.13 |
| Y27632 + H2O2 | 9 | 128.7 ± 17.98∗ | 195.4 ± 35.64 | 125.3 ± 8.51∗ |
| Y27632 + NS309 + H2O2 | 5 | 97.4 ± 4.72∗ | 9.4 ± 3.97∗ | 31.6 ± 19.23∗ |
Values are expressed as mean plus or minus SEM of 5 to 13 individual strips; ∗significantly different from corresponding value in vehicle treated group (p < 0.05).