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Intracellular signaling transduction mediated by polyphenols for the treatment of NAFLD. Polyphenols may prevent injury in hepatocytes associated with NAFLD through several signaling pathways: (1) suppressing activation of NF-κB pathway to inhibit inflammation; (2) increasing β-fatty acid oxidation by upregulating PPARα; (3) inhibiting lipogenesis via downregulation of SREBP-1c by AMPK activation; and (4) enhancing antioxidant defense through Nrf2 pathway.
