Figure 3.

The major action mechanisms of a variety of polyphenols on HSCs. Apigenin, EGCG, icaritin, curcumin, and resveratrol could inhibit the activation of HSCs; chrysin, tricin, chlorogenic acid, luteolin, resveratrol, EGCG, and wogonoside suppress the profibrogenesis function of HSCs; hyperoside, morin, gallic acid, and quercetin can induce HSC apoptosis. PDGF: platelet-derived growth factor; FGF: fibroblast growth factor; MCP-1: monocyte chemoattractant protein-1; TIMP1: TIMP metallopeptidase inhibitor 1.