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. 2018 Feb 14;13:957–973. doi: 10.2147/IJN.S152742

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© 2018 Colzani et al. This work is published and licensed by Dove Medical Press Limited

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HER2 phosphorylation.

Notes: (A) Analysis of pHER2 (Y1248) and HER2 expression on SKBR3 cells after treatment with control CTZ and RTZ at 2 µg mL⁻¹ for 4 and 24 h; (B) Analysis of HER2 expression on SKBR3 cells after treatment with PLGA-TZ at 2 µg mL⁻¹ for 4 and 24 h. Values were calculated as ratio between pHER2/HER2 and HER2/b-actin and normalized with untreated cells (UNTR).

Abbreviations: HER2, human epidermal growth factor receptor 2; CTZ, control trastuzumab; RTZ, released trastuzumab; PLGA-TZ, trastuzumab-loaded poly(lactic-co-glycolic) acid nanoparticles; UNTR, cells without treatment.