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. 2018 Feb 19;17:52. doi: 10.1186/s12943-018-0810-4

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — EML4-ALK fusion and its signaling network. a Diagram shows the fusion of the N-terminal portion of EML4, which contains its basic region, the echinoderm microtubule-associated protein-like protein (HELP) domain, and part of the WD-repeat region, to the intracellular region of ALK, containing the tyrosine kinase domain. The transmembrane (TM) domain is not present in the final fusion product. Reproduced from ref. [25]. b EML4-ALK protein complex network (interactome) constructed using a tandem affinity purification approach followed by mass spectrometry. Reproduced from ref. [39]