Table 1.

Summary of the studies in which nifurtimox was used to treat Chagas disease

Reference no.	Year	Country	No. of patients	Age (years)*	Treatment protocol	Follow-up*	Results at the end of the study
25	1977	Argentina	42	Not shown	8–10 mg/kg 60–120 days	≥ 12 months	27/29 negative XD
25	1977	Chile	15	Not shown	8–10 mg/kg 60–120 days	≥ 12 months	12/14 negative XD
25	1977	Brazil	52	Not shown	8–10 mg/kg 60–120 days	≥ 12 months	35/44 negative XD
26	1990	Brazil	50	Not shown	10–15 mg/kg 60–120 days	2 years	50% negative XD, 6% negative serology
27	1990	Argentina	39	< 17	8–10 mg/kg 60 days	139 months	11–14% negative serology, 15% negative XD
28	1997	Brazil	27	Not shown	5 mg/kg 30 days	1 year	100% positive serology, 8/83 positive XD
29	1998	Chile	28	< 10	7 mg/kg 60 days	6 months	100% negative XD, 35.8% negative PCR
30	2000	Argentina	32	13–52	5–8 mg/kg 60 days	14 years (8–23)	100% positive serology, 100% negative XD
31	2000	Brazil	28	Adults	10 mg/kg 60 days	10 years	100% positive serology, 100% positive PCR
32	2001	Chile	66	Children	Not shown	3 years	34/36 positive serology, 100% negative XD and PCR
33	2002	Brazil	10	38 (25–48)	8–9 mg/kg 60 days	303 months	100% positive serology, 9/10 positive XD
34	2003	Chile	99	Children	10 mg/kg 30 days	3 years	100% negative XD, 100% negative PCR
24	2004	Argentina	7	< 14	12–15 mg/kg 45–60 days	21 years (median)	6/7 negative serology
35	2013	Chile	21	38 (23–50)	6 mg/kg 60 days	13 months	Four patients positive PCR†
36	2013	Switzerland	37	44 (22–59)	10 mg/kg 30–60 days	4 years	100% positive serology, one patient positive PCR

PCR = polymerase chain reaction; XD = xenodiagnosis.

^*The data are expressed as mean except where noted otherwise. In some instances, the range is shown in parentheses.

^†PCR was performed in both the patient’s blood and fecal samples of Triatoma infestans nymphs.