Table 3.
Current status of the drugs used to treat Chagas disease
| Drug | Drug development | In vitro assay | In vivo Assay | Phase I studies | Phase II studies | Phase III studies | Phase IV/approved |
|---|---|---|---|---|---|---|---|
| BZ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ |
| NFX | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ |
| POSA | ✓ | ✓ | ✓ | ✓ | ✓ | – | – |
| RAVU | ✓ | ✓ | ✓ | ✓ | ✓ | – | – |
| ITRA | ✓ | ✓ | ✓ | ✓ | ✓ | – | – |
| KETO | ✓ | ✓ | ✓ | ✓ | X | – | – |
| VORI | ✓ | ✓ | ✓ | ✓ | – | – | – |
| ALBA | ✓ | ✓ | ✓ | ✓ | – | – | – |
| DO8701 | ✓ | ✓ | ✓ | – | – | – | – |
| TAK-187 | ✓ | ✓ | ✓ | – | – | – | – |
| K-777 | ✓ | ✓ | ✓ | X | – | – | – |
| FENARI | ✓ | ✓ | ✓ | Planned | – | – | – |
| FEXINI | ✓ | ✓ | ✓ | ✓ | ✓ | – | – |
| MILTEFO | ✓ | ✓ | ✓ | ✓ | – | – | – |
| EDELFO | ✓ | ✓ | – | – | – | – | – |
| ILMOFO | ✓ | ✓ | – | – | – | – | – |
| NANO BZ | ✓ | ✓ | ✓ | – | – | – | – |
| SELENIUM | ✓ | ✓ | ✓ | ✓ | ✓ | In progress | – |
| ALOPU | ✓ | ✓ | ✓ | ✓ | X | – | – |
| AMIO | ✓ | ✓ | ✓ | ✓ | In progress | – | – |
| SCYX-7158 | ✓ | ✓ | ✓ | In progress | – | – | – |
ALBA = albaconazole; ALOPU = allopurinol; AMIO = amiodarone; BZ = benznidazole; EDELFO = edelfosine; FENARI = fenarimol; FEXINI = fexinidazole; ILMOFO = ilmofosine; ITRA = Itraconazole; KETO = ketoconazole; MILTEFO = miltefosine; NANO BZ = benznidazole nanoformulated; NFX = nifurtimox; POSA = posaconazole; RAVU = ravuconazole; SCYX-7158 = oxaborole; VORI = voriconazole; X = interrupted.