Table 11.

Biological activity of nanostructured CD formulates against epimastigotes of Trypanosoma cruzi (CL strain, clone B5) after sonication

Formulate	Epimastigotes
	256 μΜ ± SD (N = 3)*	IC50 ± SD (N = 3)†
CD 12	26.9 ± 2.0	16.7 ± 4.6‡
CD 24	34.9 ± 3.2	36.9 ± 8.0
CD 52	33.0 ± 2.2	21.9 ± 1.2‡
CD 45	37.1 ± 1.2	46.7 ± 5.9
CD 48	37.9 ± 1.6	49.0 ± 2.5
BNZ	23.4 ± 0.9	26.8 ± 1.6

BNZ = benznidazole; CD = cyclodextrin; SD = standard deviation.

^*The results are the mean values of epimastigote growth at the highest concentration tested (256 μΜ) ± SD (N = 3) in three independent experiments.

^†The concentration causing 50% growth inhibition was calculated using GraphPad Prism software.

^‡Significant difference (P < 0.05) compared with free BNZ (Student’s t test).