Fig. 6.

Distinct roles of PPP2R5E and BCL2L11 in PP2A activity, proliferation and apoptosis of miR-19b-attenuated PC9 cells. a PP2A activity, (b) spontaneous (left panel) and TNFα/ActD-induced (right panel) apoptosis, (c) proliferation and (d) clonogenic growth of PC9 cells transduced with anti-miR-19b (grey columns) or anti-miR control (αscr, white columns) in combination with shcontrol (sh002, solid), shPPP2R5E (hatched) and shBCL2L11 (dotted) (n = 3). Analysis was performed as described in the legend to Fig. 4. e Model showing EGFR/AKT-induced miR-19b, its targets and cellular processes in which it is involved. ns, not significant. *, p < 0.05; **, p < 0.01; ***, p < 0.001, ****, p < 0.0001