Table 1.
Examples of oncogenic fusion proteins and their interactions with the IGF1R
| Fusion protein | Chromosomes involved | Type of tumor | Interaction with IGF1R |
|---|---|---|---|
| BCR-ABL | t(9;22) | Chronic myelogenous leukemia | IGF1R regulates the cell fate determination of BCR-ABL+ leukemia cells |
| EWSR1-FLI1 | t(22;11) | Ewing sarcoma | An intact IGF1R is required for the oncogenic action of EWSR1-FLI1 |
| TMPRSS2-ERG | t(21;22) | Prostate cancer | Overexpression of ERG leads to transactivation of the IGF1R gene |
| MYB-NFIB | t(6;9) | Adenoid cystic carcinoma (salivary gland, others) | The fusion protein is regulated via IGF1R-stimulated AKT activation |
| ETV6-NTRK3 | t(12;15) | Congenital fibrosarcoma, others | ETV6-NTRK3 forms a tripartite complex with phosphorylated IRS1 and IGF1R. This complex is critical for the oncogenic action of the chimera |
| EWSR1-WT1 | t(11;22) | Desmoplastic small round cell tumor | The chimera transactivates the IGF1R gene |