Table 5.
Renal clearance of glycation, oxidation, and nitration free adducts
| Amino acid | Renal clearance (μL/mg creatinine) | ||
|---|---|---|---|
| Healthy controls | ASD | P value | |
| FL# | 0.696 (0.375–1.16) | 0.866 (0.384–2.31) | |
| CML | 0.297 (0.249–0.387) | 0.259 (0.171–0.782) | |
| CEL | 0.0068 (0.003–0.019) | 0.0042 (0.002–0.011) | |
| G-H1 | 21.2 (13.1–34.7) | 23.9 (15.0–57.7) | |
| MG-H1# | 0.718 (0.496–1.04) | 0.628 (0.363–0.912) | |
| 3DG-H | 0.067 (0.033–0.163) | 0.087 (0.042–0.131) | |
| CMA | 1.57 (0.997–2.08) | 0.791 (0.465–1.36) | 0.0011* |
| GSP | 0.121 (0.083–0.274) | 0.112 (0.067–0.195) | |
| MOLD | 0.214 (0.075–0.487) | 0.269 (0.153–0.656) | |
| Pyrraline | 0.81 (0.58–1.17) | 1.07 (0.64–1.96) | |
| DT | 0.119 (0.657–2.02) | 0.747 (0.545–0.107) | 0.0025 |
| NFK | 0.062 (0.038–0.109) | 0.096 (0.049–0.139) | 0.030 |
| GSA | 29.9 (11.1–45.8) | 17.8 (1.96–26.1) | |
| 3-NT | 0.068 (0.034–0.100) | 0.042 (0.036–0.129) | |
Data are mean ± SD or median (lower–upper quartile); healthy controls, n = 21, and ASD, n = 27. Significance: t-test for parametric data and Mann-Whitney U for non-parametric data
*P < 0.05, after Bonferroni correction of 14 applied
#mL/mg creatinine