Table 6.

Renal clearance of amino acids

Amino acid	Renal clearance (mL/mg creatinine)
	Healthy controls	ASD	P value
Ala	1.03 (0.746–1.712)	1.27 (0.890–1.65)
Arg	0.011 (0.009–0.015)	0.008 (0.006–0.010)	0.0019*
Asn	2.80 (2.22–4.76)	4.30 (3.05–7.14)	0.0055
Asp	3.81 (3.04–4.96)	4.73 (2.92–7.82)
Cys (total)	0.646 (0.518–0.812)	0.629 (0.452–1.133)
Gln	1.18 (0.913–1.53)	1.54 (1.14–1.96)	0.025
Glu	0.210 (0.158–0.304)	0.243 (0.179–0.357	0.049
Gly	0.0050 (0.002–0.009)	0.0067 (0.004–0.029)	0.018
His	0.029 (0.024–0.040)	0.040 (0.027–0.053)
IIe	0.262 (0.192–0.347)	0.354 (0.256–0.441)	0.0116
Leu	0.358 ± 0.135	0.402 ± 0.105
Lys	0.011 (0.005–0.018)	0.0071 (0.005–0.011)
Met	0.0066 ± 0.0015	0.0056 ± 0.0023
Phe	1.32 (0.959–2.02)	1.65 (1.33–1.95)
Pro	0.077 ± 0.031	0.104 ± 0.039	0.0138
Ser	3.66 (2.95–4.79)	5.22 (3.99–6.78)	0.0081
Thr	2.023 ± 0.765	2.44 ± 1.05
Trp	0.209 (0.155–0.242)	0.287 (0.166–0.497)	0.010
Tyr	0.0209 (0.016–0.025)	0.015 (0.012–0.025)
Val	0.0017 (0.0014–0.0022)	0.0016 (0.0013–0.0026)

Data are mean ± SD or median (lower–upper quartile); healthy controls, n = 21, and ASD, n = 27. Significance: t test for parametric data and Mann-Whitney U for non-parametric data

*P < 0.05, after Bonferroni correction of 20 applied