Table 6.
Amino acid | Renal clearance (mL/mg creatinine) | ||
---|---|---|---|
Healthy controls | ASD | P value | |
Ala | 1.03 (0.746–1.712) | 1.27 (0.890–1.65) | |
Arg | 0.011 (0.009–0.015) | 0.008 (0.006–0.010) | 0.0019* |
Asn | 2.80 (2.22–4.76) | 4.30 (3.05–7.14) | 0.0055 |
Asp | 3.81 (3.04–4.96) | 4.73 (2.92–7.82) | |
Cys (total) | 0.646 (0.518–0.812) | 0.629 (0.452–1.133) | |
Gln | 1.18 (0.913–1.53) | 1.54 (1.14–1.96) | 0.025 |
Glu | 0.210 (0.158–0.304) | 0.243 (0.179–0.357 | 0.049 |
Gly | 0.0050 (0.002–0.009) | 0.0067 (0.004–0.029) | 0.018 |
His | 0.029 (0.024–0.040) | 0.040 (0.027–0.053) | |
IIe | 0.262 (0.192–0.347) | 0.354 (0.256–0.441) | 0.0116 |
Leu | 0.358 ± 0.135 | 0.402 ± 0.105 | |
Lys | 0.011 (0.005–0.018) | 0.0071 (0.005–0.011) | |
Met | 0.0066 ± 0.0015 | 0.0056 ± 0.0023 | |
Phe | 1.32 (0.959–2.02) | 1.65 (1.33–1.95) | |
Pro | 0.077 ± 0.031 | 0.104 ± 0.039 | 0.0138 |
Ser | 3.66 (2.95–4.79) | 5.22 (3.99–6.78) | 0.0081 |
Thr | 2.023 ± 0.765 | 2.44 ± 1.05 | |
Trp | 0.209 (0.155–0.242) | 0.287 (0.166–0.497) | 0.010 |
Tyr | 0.0209 (0.016–0.025) | 0.015 (0.012–0.025) | |
Val | 0.0017 (0.0014–0.0022) | 0.0016 (0.0013–0.0026) |
Data are mean ± SD or median (lower–upper quartile); healthy controls, n = 21, and ASD, n = 27. Significance: t test for parametric data and Mann-Whitney U for non-parametric data
*P < 0.05, after Bonferroni correction of 20 applied