Figure 3.

Verification of the spared nerve injury (SNI) model and the effect of paracetamol on mechanical hypersensitivity. The limb‐withdrawal response rate (A) in the hind limb ipsilateral to the operation in sham and SNI rats before drug treatment, and the drug treatment‐induced change in the limb‐withdrawal response rate in SNI (B) and sham‐operated animals (C). Paracetamol was given at the dose of 50 mg/kg. In a, the Y‐axis shows the response rate at different test stimulus forces; the higher the response rate, the stronger the hypersensitivity. In B and C, the Y‐axis shows the difference in the postdrug–predrug response at each test stimulus force; 0% represents the corresponding predrug value and differences <0% represent drug‐induced reductions in the response. All tests were performed in the nerve‐injured or sham‐operated hind limb. Error bars indicate SEM (n = 6). *P < .05, **P < .01, ***P < .005 (reference: the corresponding value in the saline‐treated group; Bonferroni‐corrected t test)