Table 1.
Tests | Saline | Low dose | Effect | High dose | Effect |
---|---|---|---|---|---|
OFT | |||||
Line crossing (#) | 52.33 ± 4.00 | 28.33 ± 7.18 | ↓ | 20.67 ± 2.04 | ↓↓ |
Rearing and Leaning (#) | 19.33 ± 1.52 | 10.83 ± 3.57 | ↔ | 5.67 ± 1.65 | ↓↓ |
Grooming time (s) | 15.83 ± 3.66 | 2.33 ± 1.31 | ↓↓ | 2.50 ± 2.50 | ↓↓ |
Defecation (#) | 1.00 ± 1.00 | 1.83 ± 1.08 | ↔ | 2.00 ± 0.58 | ↔ |
Center time (%) | 7.50 ± 1.62 | 5.72 ± 2.52 | ↔ | 5.83 ± 3.10 | ↔ |
EPM | |||||
Closed Arm Time (%) | 61.3 ± 6.76 | 64.88 ± 5.42 | ↔ | 89.06 ± 4.54 | ↑ |
LDB | |||||
Light box time (%) | 54.61 ± 3.48 | 43.44 ± 2.89 | ↔ | 38.94 ± 4.96 | ↓ |
Sucrose preference | |||||
Sucrose preference (%) | 90.79 ± 2.78 | 92.29 ± 1.66 | ↔ | 38.06 ± 11.46 | ↓↓↓ |
Rotarod | |||||
Drop latency (s) | 112.17 ± 31.73 | 143.83 ± 24.03 | ↔ | 65.33 ± 12.22 | ↔ |
OFT, Open‐Field Test; EPM, Elevated Plus Maze; LDB, Light‐Dark Box; Effect, effect vs saline; ↑, significant increase; ↓, significant decrease; ↔, no significant change. # = number. One arrow = P < .05; two arrows = P < .01; three arrows = P < .001.