Table 2.
Regional brain volumes compared between AD and PCA
| PCA | Amnestic AD | P * | |
|---|---|---|---|
| N | 19 | 68 | |
| Whole brain (mm3) |
951,948 (86,033) [797,538–1142903] |
969,757 (126,099) [655,039–1314248] |
0.07a |
| Right hippocampus (mm3) |
3514 (604) [ 2256–4584] |
3336 (449) [ 2291–4303] |
0.18b |
| Left hippocampus (mm3) |
3457 (484) [2574–4249] |
3209 (435) 2174–4141] |
0.03b |
| Right EC (mm3) |
2253 (355) [1462–2811] |
2212 (349) [1435–3150] |
0.83b |
| Left EC (mm3) |
1954 (293) [1438–2452] |
1896 (286) [1211–2524] |
0.52b |
| Right PHG (mm3) |
2892 (532) [2062–3828] |
2894 (400) [2073–3831] |
0.63b |
| Left PHG (mm3) |
3166 (565) [2186–4099] |
3064 (432) [2238–4050] |
0.47b |
| Right AG (mm3) |
6454 (1213) [4313–8436] |
6598 (1231) [3839–9522] |
0.43b |
| Left AG (mm3) |
6118 (1084) [4432–8624] |
6341 (1279) [3848–9971] |
0.31b |
| Right SPL (mm3) |
6601 (1546) [3692–9704] |
7501 (1200) [4987–9811] |
0.001b |
| Left SPL (mm3) |
6634 (1303) [4541–8899] |
7627 (1417) [4203–10,541] |
<0.001a |
| Right frontal (mm3) |
117,454 (10,627) [98,247–134,058] |
113,799 (16,065) [74,928–153,361] |
0.36b |
| Left frontal (mm3) |
117,674 (11,092) [99,542–139,374] |
113,732 (15,730) [73,511–146,192] |
0.30b |
| Right occipital (mm3) |
40,392 (5798) [31,240–52,095] |
42,783 (6570) [25,259–57,635] |
0.01b |
| Left occipital (mm3) |
38,567 (6443) [25,675–53786] |
40,677 (6025) [28,131–56,436] |
0.03b |
EC, entorhinal cortex; PHG, parahippocampal gyrus; AG, angular gyrus; SPL, superior parietal lobule.
Data presented as (mean (SD), range [ ]); *P‐values are shown for a pairwise test: null hypothesis is no differences between the groups, adjusting for TIV; ageneralized least squares linear regression, allowing for variability to differ between groups; bordinary least squares linear regression.